Testosteron Combination 250mg

52,30 

Testosterone Combination is a clear, colorless oily liquid of testosterone esters for intramuscular use. Each ml contains testosterone propionate 30 mg, testosterone phenylpropionate 60 mg, testosterone isocaproate 60 mg and testosterone decanoate 100 mg.
Testosterone is the main endogenous hormone required for the normal growth and development of male genitalia and male secondary sex characteristics. In adulthood, testosterone is essential for the function of the testes and accessory structures, as well as for the maintenance of libido, sense of well-being, erectile strength, prostate and seminal vesicle function. Treatment of hypogonadal men with Testosterone Combination results in clinically significant increases in plasma concentrations of testosterone, dihydrotestosterone and androstenedione, as well as decreases in SHBG (sex hormone binding globulin). In men with primary (hypergonadotropic) hypogonadism, treatment with Testosterone Combination leads to normalization of pituitary function.
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Description

Testosterone Combination is a clear, colorless oily liquid of testosterone esters for intramuscular use. Each ml contains testosterone propionate 30 mg, testosterone phenylpropionate 60 mg, testosterone isocaproate 60 mg and testosterone decanoate 100 mg.
Testosterone is the main endogenous hormone required for the normal growth and development of male genitalia and male secondary sex characteristics. In adulthood, testosterone is essential for the function of the testes and accessory structures, as well as for the maintenance of libido, sense of well-being, erectile strength, prostate and seminal vesicle function. Treatment of hypogonadal men with Testosterone Combination results in clinically significant increases in plasma concentrations of testosterone, dihydrotestosterone and androstenedione, as well as decreases in SHBG (sex hormone binding globulin). In men with primary (hypergonadotropic) hypogonadism, treatment with Testosterone Combination leads to normalization of pituitary function.

Pharmacokinetic data

Testosterone Combination contains several testosterone esters with different durations of action. Esters are hydrolyzed to the natural hormone testosterone as soon as they enter the general circulation. A single dose of Testosterone Combination in men results in an increase in the total plasma level of testosterone, with the peak level being reached approximately 24-48 hours (tmax) after administration. Plasma testosterone levels return to the lower end of the normal range in men after approximately 21 days. In female-to-male transsexuals, a single dose of Testosterone Combination repeated every two weeks resulted in mean testosterone levels in the tower toward the upper end of the normal male range at 2.4 and 12 months. Testosterone is metabolized through normal pathways.

Dosage and administration

In principle, doses should be adapted to the individual response of the patient. Adults: One injection of 1 ml every three weeks is usually sufficient. Adults: It should be noted that smaller and less frequent doses may achieve the same response. Children: It should be noted that smaller and less frequent doses may achieve the same response. Female-to-male transsexuals: Doses ranging from one 1 ml injection every two weeks to one 1 ml injection every four weeks are used in different specialist centres. Application Deep intramuscular injection

Contraindications

Known or suspected carcinoma of the prostate or mammary gland; Pregnancy Breastfeeding Hypersensitivity to the active substance or to any of the excipients.

Warnings

Patients, especially the elderly, with the following conditions should be monitored: – ischemic heart disease, as androgens can cause hypercholesterolemia. – latent or overt heart failure, renal dysfunction, hypertension, epilepsy or migraine (or a history of these conditions), as androgens can sometimes cause fluid and sodium retention. – skeletal metastases, as androgens may cause hypercalcemia or hypercalciuria in these patients, – signs of osteoporosis, – changes in the lipid profile

Adverse effects

The following side effects are associated with androgen therapy in general: In prepubescent boys – precocious puberty, increased frequency of erections, phallic enlargement and premature closure of the pineal gland; priapism and other signs of excessive sexual stimulation; water and sodium retention; oligospermia and reduced ejaculatory volume. Treatment should be interrupted until these symptoms disappear, after which it should be continued at a lower dose. Hoarseness can be the first symptom of a vocal change that can lead to irreversible voice loss. If signs of virilization occur, especially voice lowering, treatment should be discontinued unless the effects are desired outcomes of treatment. The following adverse effects have also been observed: acne, impaired liver function,

Drug interactions

Enzyme inducers can have an increasing or decreasing effect on testosterone levels. Therefore, it may be necessary to adjust the dose and/or the intervals between injections. Pregnancy and breast-feeding: Based on its pharmacological effect, Combined Testosterone is suspected of causing birth defects and/or other irreversible adverse effects on pregnancy outcome. Therefore, Testosterone Combination is contraindicated during pregnancy and breastfeeding.

Dosage and directions for use

Total doses above 400 mg per month are not required due to the prolonged action of the preparation. Injections more often than once every two weeks are rarely indicated. using a wet needle or a wet syringe may cause the solution to become cloudy; however, this does not affect the efficacy of the material. Parenteral medicinal products should be inspected visually for particulate matter and discoloration prior to administration when the solution and container permit. Testosterone enanthate injection is a clear, colorless to pale yellow solution.

Overdose

The acute intramuscular toxicity of combined testosterone is very low. Priapism in men is a symptom of chronic overdose. If this occurs, treatment with Testosterone Combination should be interrupted and, after the symptom disappears, resumed at a lower dose.
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Store out of the reach and sight of children. Do not store at a temperature above 30°C. Store in the original packaging or container provided. Do not use this product after the expiry date which is stated on the outer packaging. The expiration date refers to the last day of the month. Medicines should not be disposed of through sewage or household waste. Ask your pharmacist how to dispose of medicines you no longer need. These measures will help protect the environment.
Presentation
5 ampoules are packed in a plastic tray. 2 such trays are packed in a cardboard box. Not all pack sizes may be available on the market.

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